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Article

A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex.

Development (Cambridge, England) - 1 Aug 2014

Kröcher Tim, Röckle Iris, Diederichs Ute, Weinhold Birgit, Burkhardt Hannelore, Yanagawa Yuchio, Gerardy-Schahn Rita, Hildebrandt Herbert

Abstract excerpt

Polysialic acid (polySia) is a unique glycan modification of the neural cell adhesion molecule NCAM and a major determinant of brain development. Polysialylation of NCAM is implemented by the two polysialyltransferases (polySTs) ST8SIA2 and ST8SIA4. Dysregulation of the polySia-NCAM system and variation in ST8SIA2 has been linked to schizophrenia and other psychiatric disorders. Here, we show reduced interneuron...

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Identifiers

PMID: 24993945
DOI: 10.1242/dev.111773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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