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Article

Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity.

Brain : a journal of neurology - 1 Oct 2009

Hildebrandt Herbert, Mühlenhoff Martina, Oltmann-Norden Imke, Röckle Iris, Burkhardt Hannelore, Weinhold Birgit, Gerardy-Schahn Rita

Abstract excerpt

The neural cell adhesion molecule (NCAM) and its post-translational modification polysialic acid (polySia) are broadly implicated in neural development. Mice lacking the polysialyltransferases ST8SiaII and ST8SiaIV are devoid of polySia, and show severe malformation of major brain axon tracts. Here, we demonstrate how allelic variation of three interacting gene products (NCAM, ST8SiaII and ST8SiaIV) translates...

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Source

Identifiers

PMID: 19443631
DOI: 10.1093/brain/awp117

Genes

NCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity.PMID 19443631Read ↗

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