Article

O-GalNAc glycans enrich in white matter tracts and regulate nodes of Ranvier

2024-05-09

Abstract excerpt

Protein O-glycosylation is a critical modification in the brain, as genetic variants in the pathway are associated with both common and severe neuropsychiatric phenotypes. However, little is known about the most abundant type of O-glycan in the mammalian brain, which are O-GalNAc linked. Here, we determined the spatial localization, protein carriers, and cellular function of O-GalNAc glycans in mouse brain. We obs...

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Literature Corpus work: 5a86adcd-7446-500b-8c64-6556e6cf8bd1
DOI: 10.1101/2024.05.09.593410

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