Article
N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid.
Neuron - 1 Sept 1994
Ono K, Tomasiewicz H, Magnuson T, Rutishauser U
Abstract excerpt
The mutation of N-CAM in mice produces a phenotype dominated by an undersized olfactory bulb and accumulation of precursors in the subependymal layer. We demonstrate here that this defect can be duplicated by injection of an enzyme that specifically destroys the polysialic acid (PSA) moiety associated with N-CAM. Studies of BrdU-labeled and pyknotic cells suggest that this defect reflects a decrease in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.