Article
N-CAM mutation inhibits tangential neuronal migration and is phenocopied by enzymatic removal of polysialic acid.
Neuron - 1 Sept 1994
Ono K, Tomasiewicz H, Magnuson T, Rutishauser U
Abstract excerpt
The mutation of N-CAM in mice produces a phenotype dominated by an undersized olfactory bulb and accumulation of precursors in the subependymal layer. We demonstrate here that this defect can be duplicated by injection of an enzyme that specifically destroys the polysialic acid (PSA) moiety assoc...
Topics
- Animals
- Cell Adhesion Molecules, Neuronal
- Cell Death
- Cell Division
- Cell Movement
- Ependyma
- Mice
- Mice, Inbred Strains
- Mutation
- Neurons
- Olfactory Bulb
- Phenotype
- Sialic Acids