Article
Influence of interleukin 10 promoter polymorphisms in polymyalgia rheumatica: disease susceptibility and functional consequences.
Clinical and experimental rheumatology - 1 Jan 2000
Alvarez-Rodriguez Lorena, Carrasco-Marín Eugenio, Tripathi Gaurav, Muñoz-Cacho Pedro, Lopez-Hoyos Marcos, Mata Cristina, Calvo-Alén Jaime, Garcia-Unzueta Maite, Aurrecoechea Elena, Alvarez-Dominguez Carmen, Martinez-Taboada Victor M
Abstract excerpt
OBJECTIVES: To investigate the functional consequences of IL10 (-592C/A and -1082A/G) gene polymorphisms and their association with susceptibility to, and disease phenotype, in patients with polymyalgia rheumatica (PMR). METHODS: A total number of 168 with PMR and 124 age-matched controls were genotyped using allele-specific primers and restriction fragment length polymorphism analysis. The levels of circulating...
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