Article
Cytokine gene considerations in giant cell arteritis: IL10 promoter polymorphisms and a review of the literature.
Clinical reviews in allergy & immunology - 1 Aug 2014
Alvarez-Rodriguez Lorena, Lopez-Hoyos Marcos, Carrasco-Marín Eugenio, Tripathi Gaurav, Muñoz Cacho Pedro, Mata Cristina, Calvo-Alen Jaime, Garcia-Unzueta Maite, Aurrecoechea Elena, Martinez-Taboada Victor Manuel
Abstract excerpt
Polymorphisms of cytokine genes have been investigated as susceptibility markers of giant cell arteritis (GCA). Here, we have reviewed the evidence to date and especially addressed the functional consequences of IL10 (-592C/A and -1082A/G) gene polymorphisms and their association with susceptibility to and disease phenotype in GCA. A total number of 71 patients with GCA and 124 age-matched controls were genotyped...
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