Article
Interleukin-10 promoter polymorphisms in myasthenia gravis.
Journal of neuroimmunology - 29 May 2009
Alseth Espen Homleid, Nakkestad Hanne Linda, Aarseth Jan, Gilhus Nils Erik, Skeie Geir Olve
Abstract excerpt
Interleukin 10 (IL-10) is secreted by several hemopoietic cells and suppresses the Th1 mediated immune response, while stimulating B cell differentiation and the humoral immune response. IL-10 expression in Con A-stimulated peripheral blood mononuclear cells is related to three polymorphisms in the promoter region of the IL-10 gene; G/A at position -1082, T/C at position -819 and A/C at position -592. We analyzed...
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