Article
The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis.
The Journal of rheumatology - 1 Aug 2005
Riyazi Naghmeh, Kurreeman Fina A S, Huizinga Tom W J, Dekker Friedo W, Stoeken-Rijsbergen Gerrie, Kloppenburg Margreet
Abstract excerpt
OBJECTIVE: The interleukin (IL)-10 single nucleotide promoter polymorphism (SNP) -2849A is associated with decreased IL-10 production as measured by lipopolysaccharide (LPS) stimulated whole blood cultures. A low innate production of IL-10 using the same assay is associated with an increased risk of familial osteoarthritis (OA). We investigated the association of 7 novel SNP located downstream of the IL-10...
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