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Article

HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4.

Gut - 1 Mar 2022

Pham Long V, Pedersen Martin Schou, Fahnøe Ulrik, Fernandez-Antunez Carlota, Humes Daryl, Schønning Kristian, Ramirez Santseharay, Bukh Jens

Abstract excerpt

OBJECTIVE: HCV-genotype 4 infections are a major cause of liver diseases in the Middle East/Africa with certain subtypes associated with increased risk of direct-acting antiviral (DAA) treatment failures. We aimed at developing infectious genotype 4 cell culture systems to understand the evolutionary genetic landscapes of antiviral resistance, which can help preserve the future efficacy of DAA-based therapy....

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Identifiers

PMID: 33833066
DOI: 10.1136/gutjnl-2020-323585
PMCID: PMC8862099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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