Article
Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2014
Melhem Nadine M, Lu Cong, Dresbold Cara, Middleton Frank A, Klei Lambertus, Wood Shawn, Faraone Stephen V, Vinogradov Sophia, Tiobech Josepha, Yano Victor, Roeder Kathryn, Byerley William, Myles-Worsley Marina, Devlin Bernie
Abstract excerpt
An increased abundance of runs of homozygosity (ROH) has been associated with risk for various diseases, including schizophrenia. Here we investigate the characteristics of ROH in Palau, an Oceanic population, evaluating whether these characteristics are related to risk for psychotic disorders and the nature of this association. To accomplish these aims we evaluate a sample of 203 cases with schizophrenia and...
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