No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.

doi:10.1371/journal.pgen.1006343

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Article

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.

PLoS genetics - 1 Oct 2016

Johnson Emma C, Bjelland Douglas W, Howrigan Daniel P, Abdellaoui Abdel, Breen Gerome, Borglum Anders, Cichon Sven, Degenhardt Franziska, Forstner Andreas J, Frank Josef, Genovese Giulio, Heilmann-Heimbach Stefanie, Herms Stefan, Hoffman Per, Maier Wolfgang, Mattheisen Manuel, Morris Derek, Mowry Bryan, Müller-Mhysok Betram, Neale Benjamin, Nenadic Igor, Nöthen Markus M, O'Dushlaine Colm, Rietschel Marcella, Ruderfer Douglas M, Rujescu Dan, Schulze Thomas G, Simonson Matthew A, Stahl Eli, Strohmaier Jana, Witt Stephanie H, Sullivan Patrick F, Keller Matthew C

Abstract excerpt

It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism...

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PMID: 27792727
DOI: 10.1371/journal.pgen.1006343
PMCID: PMC5085024

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