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Article

Runs of homozygosity associated with speech delay in autism in a taiwanese han population: evidence for the recessive model.

PloS one - 1 Jan 2013

Lin Ping-I, Kuo Po-Hsiu, Chen Chia-Hsiang, Wu Jer-Yuarn, Gau Susan S-F, Wu Yu-Yu, Liu Shih-Kai

Abstract excerpt

Runs of homozygosity (ROH) may play a role in complex diseases. In the current study, we aimed to test if ROHs are linked to the risk of autism and related language impairment. We analyzed 546,080 SNPs in 315 Han Chinese affected with autism and 1,115 controls. ROH was defined as an extended homozygous haplotype spanning at least 500 kb. Relative extended haplotype homozygosity (REHH) for the trait-associated ROH...

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Share to Autistic Disorder
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23977206
DOI: 10.1371/journal.pone.0072056
PMCID: PMC3745408

Genes

ATM
CUL5
NPAT

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