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Article

Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007

Lencz Todd, Lambert Christophe, DeRosse Pamela, Burdick Katherine E, Morgan T Vance, Kane John M, Kucherlapati Raju, Malhotra Anil K

Abstract excerpt

Evolutionarily significant selective sweeps may result in long stretches of homozygous polymorphisms in individuals from outbred populations. We developed whole-genome homozygosity association (WGHA) methodology to characterize this phenomenon in healthy individuals and to use this genomic feature to identify genetic risk loci for schizophrenia (SCZ). Applying WGHA to 178 SCZ cases and 144 healthy controls...

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Identifiers

PMID: 18077426
DOI: 10.1073/pnas.0710021104
PMCID: PMC2148402

Genes

ATF2
NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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