Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A recessive genetic model and runs of homozygosity in major depressive disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2014

Power Robert A, Keller Matthew C, Ripke Stephan, Abdellaoui Abdel, Wray Naomi R, Sullivan Patrick F, Breen Gerome

Abstract excerpt

Genome-wide association studies (GWASs) of major depressive disorder (MDD) have yet to identify variants that surpass the threshold for genome-wide significance. A recent study reported that runs of homozygosity (ROH) are associated with schizophrenia, reflecting a novel genetic risk factor resulting from increased parental relatedness and recessive genetic effects. Here, we explore the possibility of such a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Homozygote

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 24482242
DOI: 10.1002/ajmg.b.32217
PMCID: PMC4234115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A recessive genetic model and runs of homozygosity in major depressive disorder.PMID 24482242Read ↗

No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset.Semantic proximity Read ↗

Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred.Semantic proximity Read ↗

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.Semantic proximity Read ↗

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.Semantic proximity Read ↗

Ancestry-dependent Enrichment of Deleterious Homozygotes in Runs of HomozygositySemantic proximity Read ↗

Genomic patterns of homozygosity in worldwide human populations.Semantic proximity Read ↗

Regions of homozygosity and their impact on complex diseases and traits.Semantic proximity Read ↗

Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.Semantic proximity Read ↗

Characterizing runs of homozygosity and their impact on risk for psychosis in a population isolate.Semantic proximity Read ↗

Runs of homozygosity associated with speech delay in autism in a taiwanese han population: evidence for the recessive model.Semantic proximity Read ↗

Long runs of homozygosity are enriched for deleterious variation.Semantic proximity Read ↗

Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK BiobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.