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Article

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.

PLoS genetics - 1 Jan 2012

Keller Matthew C, Simonson Matthew A, Ripke Stephan, Neale Ben M, Gejman Pablo V, Howrigan Daniel P, Lee Sang Hong, Lencz Todd, Levinson Douglas F, Sullivan Patrick F

Abstract excerpt

Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in...

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Identifiers

PMID: 22511889
DOI: 10.1371/journal.pgen.1002656
PMCID: PMC3325203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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