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Article

Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population.

Molecular psychiatry - 1 Jun 2021

Peng Qian, Ehlers Cindy L

Abstract excerpt

Runs of homozygosity (ROH) arise when an individual inherits two copies of the same haplotype segment. While ROH are ubiquitous across human populations, Native populations-with shared parental ancestry arising from isolation and endogamy-can carry a substantial enrichment for ROH. We have been investigating genetic and environmental risk factors for alcohol use disorders (AUD) in a group of American Indians (AI)...

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Identifiers

PMID: 33398086
DOI: 10.1038/s41380-020-00989-9
PMCID: PMC8254832

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