Article
High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant.
Clinical chemistry - 1 Jul 2007
Ay Cihan, Jungbauer Lea V, Sailer Thomas, Tengler Theres, Koder Silvia, Kaider Alexandra, Panzer Simon, Quehenberger Peter, Pabinger Ingrid, Mannhalter Christine
Abstract excerpt
BACKGROUND: The cell adhesion molecule P-selectin has an important role in the pathophysiology of thrombosis. The effect on venous thromboembolism (VTE) of increased circulating concentrations of soluble P-selectin (sP-selectin) and their association with the P-selectin variant Thr715Pro is still uncertain. METHODS: This study was a case-control study of 116 patients with confirmed recurrent VTE and at least 1...
Topics
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- P-Selectin
- Polymorphism, Single Nucleotide