P-selectin gene haplotypes modulate soluble P-selectin concentrations and contribute to the risk of venous thromboembolism.

doi:10.1160/TH07-11-0672

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Article

P-selectin gene haplotypes modulate soluble P-selectin concentrations and contribute to the risk of venous thromboembolism.

Thrombosis and haemostasis - 1 May 2008

Ay Cihan, Jungbauer Lea V, Kaider Alexandra, Koder Silvia, Panzer Simon, Pabinger Ingrid, Mannhalter Christine

Abstract excerpt

The cell adhesion molecule P-selectin mediates the interaction of activated platelets or endothelial cells with leukocytes. In arterial and venous thromboembolism (VTE) increased soluble P-selectin (sP-selectin) concentrations have been found, and associations of P-selectin genotypes with thrombotic disease have been proposed. We assessed the effect of four single nucleotide polymorphisms (SNPs) [one in the...

Topics

Adult
Aged
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Odds Ratio

P-Selectin

Phenotype

Pilot Projects

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 18449419
DOI: 10.1160/TH07-11-0672

Genes

SELP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18449419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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