Article
The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival.
PloS one - 1 Jan 2014
Rumaney Maryam Bibi, Ngo Bitoungui Valentina Josiane, Vorster Anna Alvera, Ramesar Raj, Kengne Andre Pascal, Ngogang Jeanne, Wonkam Ambroise
Abstract excerpt
BACKGROUND: Co-inheritance of α-thalassemia was reported to be associated with a delayed age of disease onset among Cameroonian Sickle Cell Anemia (SCA) patients. The present study aimed to explore the correlation between α-thalassemia, hematological indices, and clinical events in these patients. METHODS AND FINDINGS: We studied 161 Cameroonian SCA patients and 103 controls (59.1% HbAA) with median ages of 17.5...
Topics
- Adolescent
- Adult
- Age Factors
- Anemia, Sickle Cell
- Blood Cell Count
- Cameroon
- Female
- Gene Deletion
- Haplotypes
- Hemoglobin A