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Article

Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.

PloS one - 1 Jan 2014

Wonkam Ambroise, Ngo Bitoungui Valentina J, Vorster Anna A, Ramesar Raj, Cooper Richard S, Tayo Bamidele, Lettre Guillaume, Ngogang Jeanne

Abstract excerpt

BACKGROUND: Genetic variation at loci influencing adult levels of HbF have been shown to modify the clinical course of sickle cell disease (SCD). Data on this important aspect of SCD have not yet been reported from West Africa. We investigated the relationship between HbF levels and the relevant genetic loci in 610 patients with SCD (98% HbSS homozygotes) from Cameroon, and compared the results to a...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes, Abnormal

Share to Fetal Hemoglobin

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Source

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Identifiers

PMID: 24667352
DOI: 10.1371/journal.pone.0092506
PMCID: PMC3965431

Genes

MYB
SCD
HBB

Provenance

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