Article

Alpha-Thalassemia: Diversity of Clinical Phenotypes and Update on the Treatment

2022-11-22

Abstract excerpt

One of the more common single-gene disorders worldwide is α-thalassemia, carriers of which are found at variable frequencies (>1%) across all tropical and subtropical countries. Two linked α-globin genes on each allele of chromosome 16 regulate α-globin chain production. Deletion of one or more α-globin genes is the most frequent molecular defect found in α-thalassemia, whereas non-deletional mutations also occur,...

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Literature Corpus work: 8eec9ab3-494c-5349-a499-8a31fce3c35e
DOI: 10.3390/thalassrep12040020

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