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Article

Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon.

British journal of haematology - 1 Jan 2018

Wonkam Ambroise, Mnika Khuthala, Ngo Bitoungui Valentina J, Chetcha Chemegni Bernard, Chimusa Emile R, Dandara Collet, Kengne Andre P

Abstract excerpt

We aimed to investigate the clinical and genetic predictors of painful vaso-occlusive crises (VOC) in sickle cell disease (SCD) in Cameroon. Socio-demographics, clinical variables/events and haematological indices were acquired. Genotyping was performed for 40 variants in 17 pain-related genes, three fetal haemoglobin (HbF)-promoting loci, two kidney dysfunctions-related genes, and HBA1/HBA2 genes. Statistical...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29205277
DOI: 10.1111/bjh.15011
PMCID: PMC5847561

Genes

HBA1
HBA2
SCD
ADRB2
APOL1
COMT
DRD2
FAAH
KCNS1
MYB
OPRM1

Provenance

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