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Article

Intracellular sodium regulates proteolytic activation of the epithelial sodium channel.

The Journal of biological chemistry - 10 Oct 2008

Knight Kristin K, Wentzlaff Danielle M, Snyder Peter M

Abstract excerpt

Na(+) transport across epithelia is mediated in part by the epithelial Na(+) channel ENaC. Previous work indicates that Na(+) is an important regulator of ENaC, providing a negative feedback mechanism to maintain Na(+) homeostasis. ENaC is synthesized as an inactive precursor, which is activated...

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Identifiers

PMID: 18662987
DOI: 10.1074/jbc.M804176200
PMCID: PMC2562069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18662987-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Intracellular sodium regulates proteolytic activation of the epithelial sodium channel.PMID 18662987Read ↗

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