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Article

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

The Journal of biological chemistry - 4 Jul 2014

Haerteis Silke, Krappitz Annabel, Krappitz Matteus, Murphy Jane E, Bertog Marko, Krueger Bettina, Nacken Regina, Chung Hyunjae, Hollenberg Morley D, Knecht Wolfgang, Bunnett Nigel W, Korbmacher Christoph

Abstract excerpt

Proteolytic activation is a unique feature of the epithelial sodium channel (ENaC). However, the underlying molecular mechanisms and the physiologically relevant proteases remain to be identified. The serine protease trypsin I can activate ENaC in vitro but is unlikely to be the physiologically relevant activating protease in ENaC-expressing tissues in vivo. Herein, we investigated whether human trypsin IV, a...

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Identifiers

PMID: 24841206
DOI: 10.1074/jbc.M113.538470
PMCID: PMC4081944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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