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Article

Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.

The Journal of physiology - 1 Oct 2008

Diakov Alexei, Bera Katarzyna, Mokrushina Marianna, Krueger Bettina, Korbmacher Christoph

Abstract excerpt

The mechanisms by which proteases activate the epithelial sodium channel (ENaC) are not yet fully understood. We investigated the effect of extracellular proteases on rat ENaC heterologously expressed in Xenopus laevis oocytes. Application of trypsin increased ENaC whole-oocyte currents by about 8-fold without a concomitant increase in channel surface expression. The stimulatory effect of trypsin was preserved in...

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Identifiers

PMID: 18669538
DOI: 10.1113/jphysiol.2008.154435
PMCID: PMC2614049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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