Article
Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system
26 Jun 2014
Abstract excerpt
Human induced pluripotent stem (hiPS) cells are considered a potential source for the generation of insulin-producing pancreatic β-cells because of their differentiation capacity. In this study, we have developed a five-step xeno-free culture system to efficiently differentiate hiPS cells into insulin-producing cells in vitro. We found that a high NOGGIN concentration is crucial for specifically inducing the...
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