Article
Differentiation of human liver-derived, insulin-producing cells toward the beta-cell phenotype.
Diabetes - 1 Sept 2005
Zalzman Michal, Anker-Kitai Leeat, Efrat Shimon
Abstract excerpt
beta-Cell transplantation is viewed as a cure for type 1 diabetes; however, it is limited by the number of pancreas donors. Human stem cells offer the promise of an abundant source of insulin-producing cells, given the existence of methods for manipulating their differentiation. We have previously demonstrated that the expression of the beta-cell transcription factor pancreatic duodenal homeobox 1 (PDX-1) in...
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