Article
Introduction of two mutations into AroG increases phenylalanine production in Escherichia coli.
Biotechnology letters - 1 Oct 2014
Ding Rui, Liu Lifei, Chen Xuhui, Cui Zhenhai, Zhang Ao, Ren Daming, Zhang Lijun
Abstract excerpt
L-Phenylalanine is an important amino acid commercially, and therefore optimization of its manufacture is of interest. We constructed a range of mutant alleles of AroG, the enzyme involved in the first step of phenylalanine biosynthesis. Three single-site mutant alleles were constructed (aroG8, aroG15, and aroG29), which were then combined to generate three double-site aroG (fbr) mutant alleles (aroG8/15,...
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