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Article

Genetic engineering of Escherichia coli to improve L-phenylalanine production.

BMC biotechnology - 30 Jan 2018

Liu Yongfei, Xu Yiran, Ding Dongqin, Wen Jianping, Zhu Beiwei, Zhang Dawei

Abstract excerpt

BACKGROUND: L-phenylalanine (L-Phe) is an essential amino acid for mammals and applications expand into human health and nutritional products. In this study, a system level engineering was conducted to enhance L-Phe biosynthesis in Escherichia coli. RESULTS: We inactivated the PTS system and recruited glucose uptake via combinatorial modulation of galP and glk to increase PEP supply in the Xllp01 strain. In...

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PMID: 29382315
DOI: 10.1186/s12896-018-0418-1
PMCID: PMC5791370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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