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Phenotype-genotype mapping reveals the betaine-triggered L-arginine overproduction mechanism in Escherichia coli.

Bioresource technology - 1 Oct 2023

Jiang Shuai, Wu Heyun, Yao Zhuoyue, Li Ran, Ma Qian, Xie Xixian

Abstract excerpt

The production phenotype improvement of industrial microbes is extremely needed and challenging. Environmental factors optimization provides insightful ideas to trigger the superior production phenotype by activating potential genetic determiners. Here, phenotype-genotype mapping was used to dissect the betaine-triggered L-arginine overproduction mechanism and mine beneficial genes for further improving...

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Arginine
Betaine
Escherichia coli
Genotype
Metabolic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37488018
DOI: 10.1016/j.biortech.2023.129540

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