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Article

In vivo continuous evolution via phenotypic sorting to alleviate metabolic bottlenecks in β-alanine production.

Trends in biotechnology - 1 Feb 2026

Song Fuqiang, Zhang Heng, Wang Ke, Qiu Kun, Liu Shike, Yin Xinran, Zhang Changtai, Zhou Jingwen

Abstract excerpt

β-Alanine is an important platform chemical whose biosynthesis efficiency is limited by pathway bottlenecks and enzyme constraints. In this study, to overcome genetic interactions for β-alanine production, we systematically engineered Escherichia coli MG1655 through modular pathway optimization and combinatorial regulation. To overcome the limitations of L-aspartate-α-decarboxylase from Bacillus subtilis...

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PMID: 40940240
DOI: 10.1016/j.tibtech.2025.08.008

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