Article
A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.
The Journal of endocrinology - 1 Mar 2010
DeMambro Victoria E, Kawai Masanobu, Clemens Thomas L, Fulzele Keertik, Maynard Jane A, Marín de Evsikova Caralina, Johnson Kenneth R, Canalis Ernesto, Beamer Wesley G, Rosen Clifford J, Donahue Leah Rae
Abstract excerpt
A spontaneous mouse mutant, designated 'small' (sml), was recognized by reduced body size suggesting a defect in the IGF1/GH axis. The mutation was mapped to the chromosome 1 region containing Irs1, a viable candidate gene whose sequence revealed a single nucleotide deletion resulting in a premature stop codon. Despite normal mRNA levels in mutant and control littermate livers, western blot analysis revealed no...
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