Article
Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype.
Scientific reports - 1 Jun 2020
Fowlkes John L, Clay Bunn R, Kalaitzoglou Evangelia, Ray Phil, Popescu Iuliana, Thrailkill Kathryn M
Abstract excerpt
The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatally acquired, osteoblast-specific insulin deficiency on the pancreas-to-skeleton-to-pancreas circuit has not been studied. To explore this relationship, we created a...
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