Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leptin receptor deficient diabetic (db/db) mice are compromised in postnatal bone regeneration.

Cell and tissue research - 1 Apr 2014

Rőszer Tamás, Józsa Tamás, Kiss-Tóth Eva D, De Clerck Nora, Balogh Lajos

Abstract excerpt

Increased fragility fracture risk with improper healing is a frequent and severe complication of insulin resistance (IR). The mechanisms impairing bone health in IR are still not fully appreciated, which gives importance to studies on bone pathologies in animal models of diabetes. Mice deficient in leptin signaling are widely used models of IR and its comorbidities. Leptin was first recognized as a hormone,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Regeneration
Share to Cartilage
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Experimental

Share to Neovascularization, Physiologic

Share to Osteogenesis

Share to Radiography

Share to Receptors, Leptin

Source

Identifiers

PMID: 24343796
DOI: 10.1007/s00441-013-1768-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leptin receptor deficient diabetic (db/db) mice are compromised in postnatal bone regeneration.PMID 24343796Read ↗

The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesisSemantic proximity Read ↗

Skeletal phenotype of the leptin receptor-deficient db/db mouse.Semantic proximity Read ↗

Loss of insulin receptor in osteoprogenitor cells impairs structural strength of bone.Semantic proximity Read ↗

Mouse models of type 1 diabetes and their use in skeletal researchSemantic proximity Read ↗

ANGPTL4 binds to the leptin receptor to regulate ectopic bone formationSemantic proximity Read ↗

Diabetes Interferes with the Bone Formation by Affecting the Expression of Transcription Factors that Regulate Osteoblast DifferentiationSemantic proximity Read ↗

Potential Functions of the BMP Family in Bone, Obesity, and Glucose MetabolismSemantic proximity Read ↗

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice.Semantic proximity Read ↗

The Role of Bone Morphogenetic Proteins in Diabetic ComplicationsSemantic proximity Read ↗

Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.Semantic proximity Read ↗

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone MarrowSemantic proximity Read ↗

Leptin controls bone formation through a hypothalamic relay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.