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Article

Gain-of-Function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2021

Leanza Giulia, Fontana Francesca, Lee Seung-Yon, Remedi Maria S, Schott Céline, Ferron Mathieu, Hamilton-Hall Malcolm, Alippe Yael, Strollo Rocky, Napoli Nicola, Civitelli Roberto

Abstract excerpt

High fracture rate and high circulating levels of the Wnt inhibitor, sclerostin, have been reported in diabetic patients. We studied the effects of Wnt signaling activation on bone health in a mouse model of insulin-deficient diabetes. We introduced the sclerostin-resistant Lrp5A214V mutation, associated with high bone mass, in mice carrying the Ins2Akita mutation (Akita), which results in loss of beta cells,...

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Identifiers

PMID: 33831261
DOI: 10.1002/jbmr.4303
PMCID: PMC8360087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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