Article

Loss-of-function coding variants in the Ras of Complex Proteins/GTPase domain of Leucine Rich Repeat Kinase 2

2024-12-08

Abstract excerpt

The LRRK2 gene is a key contributor to genetic risk of Parkinson’s disease, and a priority drug target for the disorder. Leucine Rich Repeat Kinase 2, the protein product of LRRK2 , is a multidomain enzyme implicated in a range of cellular processes – including endolysosomal trafficking and damage response. Based on the report that truncation and structural variants resulting in loss of LRRK2 protein are observe...

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Literature Corpus work: 3c1004f8-5228-58f4-bb7b-d025a0b9eaef
DOI: 10.1101/2024.12.07.627348

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