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Article

Assessment of CYP450 genetic variability effect on methadone dose and tolerance.

Pharmacogenomics - 1 May 2014

Tsai Hui-Ju, Wang Sheng-Chang, Liu Sheng-Wen, Ho Ing-Kang, Chang Yao-Sheng, Tsai Yu-Ting, Lin Keh-Ming, Liu Yu-Li

Abstract excerpt

AIM: Methadone dose is related to treatment success in individuals under methadone maintenance treatment (MMT). We constructed a gene matrix using previously identified genetic polymorphisms in CYP450 and determined their genetic influence on methadone dose or tolerance. MATERIALS & METHODS: The allelic combinations of CYP450 genetic variants (two from CYP2C19, four from CYP2B6 and five from CYP3A4) were analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24956251
DOI: 10.2217/pgs.14.19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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