Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability and clinical efficacy of morphine.

Acta anaesthesiologica Scandinavica - 1 Aug 2005

Klepstad P, Dale O, Skorpen F, Borchgrevink P C, Kaasa S

Abstract excerpt

The individual variability of opioid pharmacology suggests that the patients' genetic disposition influences the response to opioids. Given the complexity of morphine pharmacology, variability may be caused by several genes. We review data which shows that variability in genes coding the enzyme metabolizing morphine (UGT2B7 gene), mu-opioid receptors (OPRM gene) and blood-brain barrier (BBB) transport of morphine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catechol O-Methyltransferase
Share to COMT gene
Share to Genes, MDR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Glucuronosyltransferase

Share to Morphine

Share to Pharmacological Effects and Toxicity Studies

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 16045647
DOI: 10.1111/j.1399-6576.2005.00772.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability and clinical efficacy of morphine.PMID 16045647Read ↗

[Genetic variation-- important for the clinical effect of opioids?].Semantic proximity Read ↗

Role of pharmacogenetics in variable response to drugs: focus on opioidsSemantic proximity Read ↗

Pain polymorphisms and opioids: An evidence based reviewSemantic proximity Read ↗

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review.Semantic proximity Read ↗

Review of Opioid Pharmacogenetics and Considerations for Pain ManagementSemantic proximity Read ↗

Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice.Semantic proximity Read ↗

Pharmacogenetics of analgesics: toward the individualization of prescription.Semantic proximity Read ↗

A Review of the Role of Genetic Testing in Pain MedicineSemantic proximity Read ↗

Clinical implications of opioid pharmacogenetics.Semantic proximity Read ↗

Reviewing pharmacogenetics to advance precision medicine for opioidsSemantic proximity Read ↗

The pharmacogenetics of analgesiaSemantic proximity Read ↗

Variations in critical morphine biosynthesis genes and their potential to influence human health.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.