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Article

Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.

PloS one - 12 May 2011

Fonseca Francina, de la Torre Rafael, Díaz Laura, Pastor Antonio, Cuyàs Elisabet, Pizarro Nieves, Khymenets Olha, Farré Magí, Torrens Marta

Abstract excerpt

Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, the influence of methadone pharmacokinetics in dose requirement and clinical outcome remains controversial. The aim of this study is to analyze methadone dosage in responder and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

Open in PubMed Open full text

Identifiers

PMID: 21589866
DOI: 10.1371/journal.pone.0019527
PMCID: PMC3093392

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21589866-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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