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Insights into the evolution and domain structure of ataxin-2 proteins across eukaryotes

15 Jul 2014

Abstract excerpt

BACKGROUND: Ataxin-2 is an evolutionarily conserved protein first identified in humans as responsible for spinocerebellar ataxia type 2 (SCA2). The molecular basis of SCA2 is the expansion of a polyglutamine tract in Ataxin-2, encoding a Lsm domain that may bind RNA and a PAM2 motif that enables interaction with the poly (A) binding protein. Although the association with SCA2 has been verified, a detailed...

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PMID: 25027299
DOI: 10.1186/1756-0500-7-453

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