Article
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Cell reports - 10 Jul 2014
Gupta Arun, Hunt Clayton R, Hegde Muralidhar L, Chakraborty Sharmistha, Chakraborty Sharmistha, Udayakumar Durga, Horikoshi Nobuo, Singh Mayank, Ramnarain Deepti B, Hittelman Walter N, Namjoshi Sarita, Asaithamby Aroumougame, Hazra Tapas K, Ludwig Thomas, Pandita Raj K, Tyler Jessica K, Pandita Tej K
Abstract excerpt
Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and that phosphorylated MOF colocalizes with γ-H2AX, ATM, and 53BP1 foci. Mutation of the phosphorylation site (MOF-T392A)...
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