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Article

Kinetics of the UV‐induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication

14 Dec 2009

Abstract excerpt

It has been reported that exposure to UV light triggers DNA damage response (DDR) seen as induction of gammaH2AX not only in S- but also in G(1)-phase cells. In the present study, in addition to gammaH2AX, we assessed other markers of DDR, namely phosphorylation of ATM on Ser1981, of ATM/ATR substrate on Ser/Thr at SQ/TQ cluster domains and of the tumor suppressor p53 on Ser15, in human pulmonary carcinoma A549...

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PMID: 20014310
DOI: 10.1002/cyto.a.20839

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