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Article

M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.

The Journal of biological chemistry - 19 Sept 2003

Lin Horng-Ru, Ting Nicholas S Y, Qin Jun, Lee Wen-Hwa

Abstract excerpt

BRCA2 is a breast tumor susceptibility gene encoding a 390-kDa protein with functions in maintaining genomic stability and cell cycle progression. Evidence has been accumulated to support the concept that BRCA2 has a critical role in homologous recombination of DNA double-stranded breaks by interacting with RAD51. In addition, BRCA2 may have chromatin modifying activity through interaction with a histone...

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Source

Identifiers

PMID: 12815053
DOI: 10.1074/jbc.M210659200

Genes

BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.PMID 12815053Read ↗

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.Semantic proximity Read ↗

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.Semantic proximity Read ↗

CIP2A coordinates phosphosignaling, mitosis, and the DNA damage responseSemantic proximity Read ↗

BRCA1 is regulated by Chk2 in response to spindle damage.Semantic proximity Read ↗

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks.Semantic proximity Read ↗

TOPBP1-PLK1 interaction preserves genome integrity during mitosis.Semantic proximity Read ↗

Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells.Semantic proximity Read ↗

A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombinationSemantic proximity Read ↗

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Semantic proximity Read ↗

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.Semantic proximity Read ↗

Polo-like kinase 1 (PLK1) O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma.Semantic proximity Read ↗

Mitotic phosphorylation of MPP8 by cyclin-dependent kinases regulates chromatin dissociation.Semantic proximity Read ↗

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