Article

CDK-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

2020-09-29

Abstract excerpt

Fanconi anemia (FA) is a rare genetic disease characterized by increased risk for bone marrow failure and cancer. The FA proteins function together to repair damaged DNA. A central step in the activation of the FA pathway is the monoubiquitination of the FANCD2 and FANCI proteins under conditions of cellular stress and during S-phase of the cell cycle. The regulatory mechanisms governing S-phase monoubiquitination...

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Literature Corpus work: a1878a6f-ae38-5efe-9e2b-fa02c3b1f3e6
DOI: 10.1101/2020.09.29.318055

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