Article
Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia.
Endocrine-related cancer - 1 Aug 2014
Papathomas Thomas G, Oudijk Lindsey, Zwarthoff Ellen C, Post Edward, Duijkers Floor A, van Noesel Max M, Hofland Leo J, Pollard Patrick J, Maher Eamonn R, Restuccia David F, Feelders Richard A, Franssen Gaston J H, Timmers Henri J, Sleijfer Stefan, de Herder Wouter W, de Krijger Ronald R, Dinjens Winand N M, Korpershoek Esther
Abstract excerpt
Hotspot mutations in the promoter of the telomerase reverse transcriptase (TERT) gene have been recently reported in human cancers and proposed as a novel mechanism of telomerase activation. To explore TERT promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia, a set of 253 tumors (38 adrenocortical carcinomas (ACCs), 127 pheochromocytomas (PCCs), 18 extra-adrenal...
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