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Article

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors.

Endocrine-related cancer - 1 Jun 2014

Liu Tiantian, Brown Taylor C, Juhlin C Christofer, Andreasson Adam, Wang Na, Bäckdahl Martin, Healy James M, Prasad Manju L, Korah Reju, Carling Tobias, Xu Dawei, Larsson Catharina

Abstract excerpt

The telomerase reverse transcriptase gene (TERT) encodes the reverse transcriptase component of the telomerase complex, which is essential for telomere stabilization and cell immortalization. Recent studies have demonstrated a transcriptional activation role for the TERT promoter mutations C228T and C250T in many human cancers, as well as a role in aggressive disease with potential clinical applications. Although...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24803525
DOI: 10.1530/ERC-14-0016
PMCID: PMC4045219

Genes

TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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