TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.

doi:10.1038/srep29714

Article

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.

Scientific reports - 14 Jul 2016

Vinagre João, Nabais Joana, Pinheiro Jorge, Batista Rui, Oliveira Rui Caetano, Gonçalves António Pedro, Pestana Ana, Reis Marta, Mesquita Bárbara, Pinto Vasco, Lyra Joana, Cipriano Maria Augusta, Ferreira Miguel Godinho, Lopes José Manuel, Sobrinho-Simões Manuel, Soares Paula

Abstract excerpt

One of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes.

Abstract excerpt

Topics

Related research