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Article

Telomerase reverse transcriptase promoter alterations across cancer types as detected by next-generation sequencing: A clinical and molecular analysis of 423 patients.

Cancer - 15 Mar 2018

Schwaederle Maria, Krishnamurthy Nithya, Daniels Gregory A, Piccioni David E, Kesari Santosh, Fanta Paul T, Schwab Richard B, Patel Sandip P, Parker Barbara A, Kurzrock Razelle

Abstract excerpt

BACKGROUND: Telomerase reverse transcriptase (TERT) promoter mutations that may affect telomerase activity have recently been described in human malignancies. The purpose of this study was to investigate the clinical correlates of TERT promoter abnormalities in a large cohort of patients with diverse cancers. METHODS: This study analyzed TERT promoter alterations and clinical characteristics of 423 consecutive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 29211306
DOI: 10.1002/cncr.31175
PMCID: PMC5839978

Genes

TERT
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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