Article
TERT Copy Number Alterations, Promoter Mutations and Rearrangements in Adrenocortical Carcinomas.
Endocrine pathology - 1 Jun 2022
Gupta Sounak, Won Helen, Chadalavada Kalyani, Nanjangud Gouri J, Chen Ying-Bei, Al-Ahmadie Hikmat A, Fine Samson W, Sirintrapun Sahussapont J, Strong Vivian E, Raj Nitya, Lagunes Diane Reidy, Vanderbilt Chad M, Berger Michael F, Ladanyi Marc, Dogan Snjezana, Tickoo Satish K, Reuter Victor E, Gopalan Anuradha
Abstract excerpt
Molecular characterization of adrenocortical carcinomas (ACC) by The Cancer Genome Atlas (TCGA) has highlighted a high prevalence of TERT alterations, which are associated with disease progression. Herein, 78 ACC were profiled using a combination of next generation sequencing (n = 76) and FISH (n = 9) to assess for TERT alterations. This data was combined with TCGA dataset (n = 91). A subset of borderline...
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