Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessment of PALB2 as a candidate melanoma susceptibility gene.

PloS one - 1 Jan 2014

Aoude Lauren G, Xu Mai, Zhao Zhen Zhen, Kovacs Michael, Palmer Jane M, Johansson Peter, Symmons Judith, Trent Jeffrey M, Martin Nicholas G, Montgomery Grant W, Brown Kevin M, Hayward Nicholas K

Abstract excerpt

Partner and localizer of BRCA2 (PALB2) interacts with BRCA2 to enable double strand break repair through homologous recombination. Similar to BRCA2, germline mutations in PALB2 have been shown to predispose to Fanconi anaemia as well as pancreatic and breast cancer. The PALB2/BRCA2 protein interaction, as well as the increased melanoma risk observed in families harbouring BRCA2 mutations, makes PALB2 a candidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fanconi Anemia Complementation Group N Protein

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Skin Neoplasms

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24949998
DOI: 10.1371/journal.pone.0100683
PMCID: PMC4065098

Genes

PALB2
BRCA2
BAP1
CDK4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessment of PALB2 as a candidate melanoma susceptibility gene.PMID 24949998Read ↗

Mutation analysis of the PALB2 cancer predisposition gene in familial melanoma.Semantic proximity Read ↗

Two PALB2 germline mutations found in both BRCA1+ and BRCAx familial breast cancer.Semantic proximity Read ↗

Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.Semantic proximity Read ↗

PALB2 Variants: Protein Domains and Cancer Susceptibility.Semantic proximity Read ↗

Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.Semantic proximity Read ↗

Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.Semantic proximity Read ↗

Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.Semantic proximity Read ↗

Management of PALB2 ‐associated breast cancer: A literature review and case reportSemantic proximity Read ↗

Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2.Semantic proximity Read ↗

Spectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China.Semantic proximity Read ↗

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

PALB2: research reaching to clinical outcomes for women with breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.